LINC complexes are evolutionarily conserved nuclear envelope bridges. composed of SUN (Sad-1/UNC-84) and KASH (Klarsicht/ANC-1/Syne/homology) domain proteins. They are crucial for nuclear positioning and nuclear shape determination. and also mediate nuclear envelope (NE) attachment of meiotic telomeres. https://parisnaturalfoodes.shop/product-category/lions-mane/
Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function.
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